NASA performed a study called HOPE (Revolutionary Concepts for Human Outer Planet Exploration) regarding the future exploration of the Solar System. The target chosen was Callisto due to its distance from Jupiter, and thus the planet's harmful radiation. It could be possible to build a surface base that would produce fuel for further exploration of the Solar System.
Three of the Galilean moons (Europa, Ganymede, Callisto) have an abundance of volatiles that may support colonization efforts.
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